Bile pigments: newcomers to the cell signaling arena.
نویسنده
چکیده
The article highlighted in this issue is "2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Accumulation of Biliverdin and Hepatic Peliosis in Rats," by Marjo Nittynen, Jouni T. Tuomisto, Seppo Auriola, Raimo Pohjanvirta, Paula Syrjälä, Ulla Simanainen, Matti Viluksela, and Jouko Tuomisto (pp. 112-123).
منابع مشابه
Bile Pigments in Pulmonary and Vascular Disease
The bile pigments, biliverdin, and bilirubin, are endogenously derived substances generated during enzymatic heme degradation. These compounds have been shown to act as chemical antioxidants in vitro. Bilirubin formed in tissues circulates in the serum, prior to undergoing hepatic conjugation and biliary excretion. The excess production of bilirubin has been associated with neurotoxicity, in pa...
متن کامل36. Coupled Oxidation of Ascorbic Acid and Haemoglobin 5. Studies on the Formation of Bile Pigments from Choleglobin and Verdohaemochromogen and on Their Isolation from Erythrocytes1
IN a preliminary paper [Lemberg, Legge & Lockwood, 1938] we have already reported the isQlation of biliverdin (dehydrobilirubin) and of biliviolin from. choleglobin solutions. Under remarkably mild conditions haemoglobin is thus transformed. into bile pigments; these conditions are such as are found in the cells of organs forming bile pigment, except that acid was used for the removal of the ir...
متن کاملHepatic accumulation and intracellular binding of conjugated bilirubin.
After the intravenous injection of unconjugated [(3)H]bilirubin into normal Sprague-Dawley and Wistar R rats, radiolabeled bile pigments rapidly accumulated in the liver. By 1.5 min after injection, an average of 36% of the injected isotope was present in liver homogenates. Between 3 and 15 min, 37-64% of the total intrahepatic radiolabeled bilirubin was conjugated, as demonstrated by extractio...
متن کاملComparison of Cytotoxic Activity of Bile on HepG2 and CCRF-CEM Cell Lines: An in Vitro Study
The aim of this study was to examine the effect of crude bile on the human HepG2 and CCRF-CEM cell lines. Cells were exposed to different dilutions of bile. Antiproliferative effects were determined by the cytotoxic MTT assay. Cells undergoing apoptosis were identified by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay. Bile administration resulted in dose-dependent c...
متن کاملSeparation by thin-layer chromatography and structure elucidation of bilirubin conjugates isolated from dog bile.
1. A system for separation of bile pigments by t.l.c. and for their structure elucidation is presented. Separated bile pigments are characterized by t.l.c. of derived dipyrrolic azopigments. 2. At the tetrapyrrolic stage hydrolysis in strongly alkaline medium followed by t.l.c. demonstrates the presence of bilirubin-IIIalpha, -IXalpha and -XIIIalpha and allows assessment of their relative amoun...
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عنوان ژورنال:
- Toxicological sciences : an official journal of the Society of Toxicology
دوره 71 1 شماره
صفحات -
تاریخ انتشار 2003